Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and links to their rpeorts go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 2345
interventional 1641
Observational 638
Registry 66

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 317
Other 272
Behavioral 214
Drug 203
Procedure 167
Drug|placebo 144
Device|Other 50
Biological 39
Behavioral|Other 26
Device|Procedure 21
Device|Drug 16
Drug|Other 16
Drug|Procedure 14
Dietary Supplement 13
Diagnostic Test 12
Dietary Supplement|placebo 12
Other|Procedure 12
Behavioral|Device 7
Biological|placebo 7
Behavioral|Drug 6
Combination Product 6
Behavioral|placebo 5
Biological|Other 5
Biological|Procedure 5
Drug|Other|placebo 5
Drug|placebo|Procedure 4
Other|placebo 4
Biological|Device 3
Biological|Drug 3
Device|placebo 3
Drug|Other|Procedure 3
Radiation 3
Behavioral|Drug|placebo 2
Device|Drug|Procedure 2
placebo|Procedure 2
Behavioral|Device|Procedure 1
Behavioral|Diagnostic Test 1
Behavioral|Drug|Procedure 1
Behavioral|placebo|Procedure 1
Biological|Diagnostic Test 1
Biological|Drug|placebo|Procedure 1
Biological|Drug|Procedure 1
Combination Product|Device 1
Combination Product|Other 1
Device|Diagnostic Test 1
Device|Diagnostic Test|Other 1
Device|Drug|Other|Procedure 1
Dietary Supplement|Drug 1
Dietary Supplement|Other 1
Drug|Radiation 1
Genetic 1
placebo 1
Procedure|Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 728
NA 98
Canada 97
China 59
France 56
United Kingdom 45
Spain 38
Denmark 35
Korea, Republic of 34
Sweden 34
Germany 32
Brazil 25
Italy 23
Switzerland 22
Norway 20
Turkey 20
Egypt 19
United States|Canada 19
Taiwan 15
Finland 13
Israel 12
Netherlands 12
India 10
Thailand 9
Belgium 8
Iran, Islamic Republic of 8
Poland 8
Malaysia 7
Pakistan 7
Hong Kong 6
Australia 5
Austria 5
Japan 5
Mexico 4
Russian Federation 4
South Africa 4
Colombia 3
Greece 3
Iceland 3
Slovenia 3
Argentina 2
Australia|New Zealand 2
Chile 2
Congo 2
Hungary 2
Iraq 2
Jordan 2
New Zealand 2
Saudi Arabia 2
Afghanistan 1
Australia|Austria|Canada|France|Germany|Israel|Singapore|South Africa|United Kingdom 1
Australia|Finland|France|Germany|Ireland|New Zealand|Saudi Arabia 1
Australia|France|New Zealand|Qatar|Saudi Arabia|Switzerland 1
Austria|Bulgaria|Czechia|Finland|Germany|Poland 1
Austria|Czech Republic|Germany 1
Austria|France|Germany|Spain|United Kingdom 1
Austria|France|Spain|Switzerland|United Kingdom 1
Belgium|France 1
Belgium|France|Germany 1
Cameroon 1
Canada|France|Israel 1
Canada|Switzerland 1
China|Taiwan 1
Cyprus 1
Czech Republic 1
Czechia|Germany|Italy|Spain|Switzerland 1
Denmark|Germany|Netherlands|Norway|United Kingdom 1
Finland|Norway|Sweden 1
France|Greece|Latvia|Spain 1
France|Guadeloupe 1
Georgia 1
Germany|Spain|Switzerland 1
Indonesia 1
Iraq|Jordan 1
Ireland 1
Lebanon 1
Lithuania 1
Luxembourg 1
Netherlands|Switzerland 1
Panama 1
Philippines 1
Portugal 1
Puerto Rico 1
Qatar 1
Rwanda 1
Singapore 1
Uganda 1
Ukraine 1
United States|Argentina|Australia|Brazil|Canada|Colombia|Czechia|Denmark|France|Germany|India|Italy|Kenya|Peru|Philippines|Poland|South Africa|Spain|United Kingdom 1
United States|Argentina|Austria|Belgium|China|Czech Republic|Finland|France|Germany|Hungary|Israel|Italy|Malaysia|Netherlands|Romania|Russian Federation|Singapore|Spain|Taiwan|Thailand|United Kingdom 1
United States|Australia 1
United States|Australia|Austria|Belgium|Brazil|Canada|China|Finland|France|Germany|Ireland|Italy|New Zealand|Switzerland|United Kingdom 1
United States|Australia|Belgium|Canada|New Zealand|Spain 1
United States|Australia|Belgium|Czechia|France|Germany|Italy|Poland|Russian Federation|Spain|Switzerland|United Kingdom 1
United States|Australia|Canada 1
United States|Australia|Canada|India|Norway 1
United States|Australia|Germany|India|United Kingdom 1
United States|Australia|India|Italy|Romania|Ukraine 1
United States|Austria|Germany|Israel 1
United States|Austria|Ireland 1
United States|Brazil|Canada 1
United States|Canada|Czech Republic|France|Poland|Spain|United Kingdom 1
United States|Canada|Germany 1
United States|Canada|India 1
United States|Canada|New Zealand 1
United States|Chile|China|Colombia|Czech Republic|Hong Kong|India|Japan|Philippines|Russian Federation 1
United States|China 1
United States|Czechia|Denmark|Sweden 1
United States|Denmark 1
United States|Denmark|Germany 1
United States|Germany|Hungary|Poland 1
United States|Italy 1
United States|Japan|Ukraine 1
United States|Puerto Rico 1

Sites per Study

Site_count Study_Count
1 1291
2 121
3 44
4 28
5 28
6 16
7 11
8 10
9 8
10 7
11 4
12 3
13 6
14 4
15 4
16 5
17 7
18 2
19 2
20 3
21 3
22 1
24 2
25 1
26 1
27 1
28 1
29 3
30 3
31 1
33 1
34 2
36 2
39 1
41 4
43 2
45 1
66 2
67 1
82 1
105 1
110 1
156 1

Phase

Phase Study_Count
N/A 1084
Phase 2 166
Phase 4 119
Phase 3 89
Phase 1 70
Phase 1/Phase 2 68
Phase 2/Phase 3 31
Early Phase 1 14

Number of Arms

Number_of_Arms Count_of_Studies
1 294
2 1063
3 127
4 51
5 12
6 12
7 1
8 1
9 1
10 1
11 1
12 2
16 1
NA 74

Number of Updates

Count of Versions Count of Studies
1 231
2 268
3 242
4 213
5 163
6 111
7 99
8 86
9 46
10 40
11 20
12 27
13 16
14 13
15 8
16 12
17 6
18 6
19 5
20 7
21 3
22 1
25 2
26 1
27 1
28 1
29 1
30 1
33 1
45 1
47 2
52 1
53 1
65 1
74 1
77 1
120 1
132 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 6987 1410 4.955319
Contacts/Locations 2980 1170 2.547009
Recruitment Status 1916 1176 1.629252
None (earliest Version on record) 1641 1641 1.000000
Study Design 1322 942 1.403397
Outcome Measures 1037 665 1.559398
Sponsor/Collaborators 758 534 1.419476
Eligibility 751 467 1.608137
Arms 743 507 1.465483
Interventions 743 507 1.465483
Study Description 696 469 1.484009
Study Identification 554 398 1.391960
Oversight 493 415 1.187952
Conditions 252 207 1.217391
References 246 159 1.547170
Results 204 204 1.000000
IPDSharing 197 180 1.094444
More Information 151 81 1.864197
Results Submission Events 103 103 1.000000
Documents 66 63 1.047619
Baseline Characteristics 46 38 1.210526
Reported Adverse Events 25 21 1.190476
Participant Flow 21 19 1.105263
2020 Outcome Measures 2 2 1.000000
2020 Study Status 1 1 1.000000
2020Recruitment Status 1 1 1.000000
Quality Control Review has not concludedReturned: February 13 1 1 1.000000
Quality Control Review has not concludedReturned: February 18 1 1 1.000000
Quality Control Review has not concludedReturned: June 4 1 1 1.000000
Quality Control Review has not concludedReturned: March 5 1 1 1.000000

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 4.00 1.000 3 1.00000 2.0000 2.0000 10.000 2.0000
1st Qu. 10.00 29.000 10 16.75000 33.0000 30.5000 81.000 31.2500
Median 18.00 60.000 20 27.50000 60.0000 60.0000 187.000 65.5000
Mean 38.50 1173.539 30 44.83824 704.1867 100.3871 1007.545 142.4661
3rd Qu. 43.75 143.000 39 50.00000 120.7500 149.0000 461.750 138.5000
Max. 201.00 949609.000 120 600.00000 100000.0000 351.0000 28669.000 2300.0000

Trial Group Type

group_type Group_Count
Experimental 1517
Active Comparator 840
Placebo Comparator 321
No Intervention 277
Other 170
Sham Comparator 97
NA 74

Intervention Model

intervention_model Study_Count
Parallel Assignment 1089
Single Group Assignment 379
Crossover Assignment 114
Factorial Assignment 39
Sequential Assignment 13
NA 7

Primary Purpose

primary_purpose Study_Count
Treatment 1057
Prevention 260
Supportive Care 78
Other 63
Diagnostic 58
Basic Science 40
Health Services Research 32
NA 31
Screening 12
Device Feasibility 10

Observational Studies

Studies by Country

Country Study_Count
United States 238
NA 59
France 40
China 31
Canada 25
United Kingdom 25
Switzerland 19
Germany 17
Italy 12
Denmark 11
Austria 10
Finland 10
Israel 9
Spain 9
Sweden 9
Turkey 9
Taiwan 8
United States|Canada 7
Belgium 6
Korea, Republic of 6
Netherlands 6
Czechia 5
Egypt 5
India 5
Brazil 4
Norway 4
Ireland 3
Poland 3
Australia 2
Greece 2
Russian Federation 2
United States|Germany 2
United States|Germany|Hungary 2
Algeria 1
Argentina 1
Australia|India|Korea, Republic of|Singapore|Thailand 1
Austria|Bulgaria|Croatia|France|Germany|Ireland|Italy|Netherlands|Romania|Serbia|Turkey|United Kingdom 1
Bosnia and Herzegovina 1
China|Taiwan 1
Denmark|Norway 1
Finland|United Kingdom 1
France|Spain 1
Germany|Greece|Italy|United Kingdom 1
Haiti 1
Iran, Islamic Republic of 1
Italy|Slovenia|Switzerland|United Kingdom 1
Jamaica 1
Jordan 1
Malaysia 1
Norway|Sweden 1
Pakistan 1
Qatar 1
Singapore 1
Slovenia 1
South Africa 1
Thailand 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Netherlands|Spain|Sweden|Switzerland|United Kingdom 1
United States|Austria|Belgium|Germany|Spain|United Kingdom 1
United States|Austria|Canada|France|Germany|Spain|Sweden|United Kingdom 1
United States|Austria|Canada|United Kingdom 1
United States|Bolivia|Canada|Chile|India|United Kingdom 1
United States|China|Israel|Norway|Palestinian Territory, occupied|Russian Federation|Sweden 1
United States|Estonia|Germany|Italy|Lithuania|Netherlands|Norway|Slovenia 1
United States|Greece|Ireland|Italy|Netherlands|Spain|Switzerland 1
United States|Hungary 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 528
2 36
3 15
4 10
5 8
6 3
7 4
8 2
9 3
10 4
11 1
12 1
13 1
14 1
15 2
16 1
17 3
18 1
19 1
21 2
22 1
23 2
24 1
28 1
33 1
35 1
39 1
44 1
58 1
371 1

Number of Updates

Count of Versions Count of Studies
1 110
2 135
3 113
4 60
5 54
6 46
7 22
8 23
9 13
10 12
11 10
12 2
13 3
14 4
15 5
17 1
18 5
20 1
21 4
22 1
24 2
26 1
28 1
30 1
34 1
35 1
47 1
49 1
59 1
73 1
83 1
100 2

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 2682 528 5.079546
Contacts/Locations 918 387 2.372093
None (earliest Version on record) 638 638 1.000000
Recruitment Status 629 410 1.534146
Study Design 472 334 1.413174
Study Description 346 174 1.988506
Eligibility 290 175 1.657143
Sponsor/Collaborators 285 200 1.425000
Outcome Measures 246 180 1.366667
Study Identification 192 130 1.476923
Groups 175 121 1.446281
Interventions 175 121 1.446281
Oversight 115 97 1.185567
References 107 64 1.671875
Conditions 90 74 1.216216
IPDSharing 47 44 1.068182
Results 27 27 1.000000
More Information 20 15 1.333333
Results Submission Events 9 9 1.000000
Baseline Characteristics 8 6 1.333333
Participant Flow 7 5 1.400000
Documents 6 5 1.200000
Reported Adverse Events 6 5 1.200000

Enrollment Metrics

Measure Observational
Min 1.00
1st Qu 50.00
Median 129.00
Mean 13594.53
3rd Qu 400.00
Max 3255526.00

Observation Model

observational_model Study_Count
Cohort 391
Case-Only 68
Case-Control 60
Case Control 40
Other 37
NA 30
Ecologic or Community 5
Case-Crossover 4
Defined Population, Natural History 3

Time Perspective

time_perspective Study_Count
Prospective 444
Retrospective 105
Cross-Sectional 56
Other 20
NA 9
Longitudinal, Prospective 3
Cross-Sectional, Prospective 1

Registries

Studies by Country

Country Study_Count
United States 17
NA 8
Korea, Republic of 4
Sweden 4
Canada 3
China 3
Denmark 3
Switzerland 3
Brazil 2
Egypt 2
Italy 2
Kenya 2
Norway 2
Turkey 2
Austria 1
Belgium 1
Czech Republic 1
Ethiopia 1
Iraq 1
Israel 1
Taiwan 1
Thailand 1
United States|Australia|Canada|China|Indonesia|Italy|Korea, Republic of|Serbia|Singapore|United Kingdom 1

Sites per Study

Site_count Study_Count
1 57
2 2
3 1
4 1
12 1
14 1
15 1
18 1
32 1

Number of Updates

Count of Versions Count of Studies
1 15
2 13
3 21
4 8
5 3
6 1
7 2
10 2
13 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 138 51 2.705882
None (earliest Version on record) 66 66 1.000000
Contacts/Locations 60 38 1.578947
Recruitment Status 47 34 1.382353
Study Design 37 31 1.193548
Eligibility 18 14 1.285714
Outcome Measures 16 12 1.333333
Study Description 16 16 1.000000
Sponsor/Collaborators 11 10 1.100000
Study Identification 9 8 1.125000
Groups 8 7 1.142857
Interventions 8 7 1.142857
Conditions 5 4 1.250000
IPDSharing 5 4 1.250000
Oversight 4 4 1.000000
References 4 4 1.000000
Documents 2 2 1.000000
Baseline Characteristics 1 1 1.000000
More Information 1 1 1.000000
Reported Adverse Events 1 1 1.000000
Results 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 7.000
1st Qu 70.000
Median 240.000
Mean 5071.712
3rd Qu 1200.000
Max 175000.000

Registry Model

observational_model Study_Count
Cohort 44
Case-Only 10
Case-Control 7
Other 2
NA 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 55
Other 6
Cross-Sectional 4
NA 1

Follow-up

target_duration Study_Count
6 Months 8
12 Months 6
1 Year 5
5 Years 5
1 Day 4
1 Month 4
28 Days 4
3 Years 4
2 Years 3
3 Months 3
30 Days 3
3 Weeks 2
1 Week 1
120 Days 1
14 Days 1
14 Months 1
16 Years 1
2 Months 1
2 Weeks 1
24 Weeks 1
3 Days 1
4 Months 1
4 Weeks 1
4 Years 1
5 Weeks 1
90 Days 1
99 Years 1